Developmental neurotoxicity guideline study: Issues with methodology, evaluation and regulation*
نویسندگان
چکیده
منابع مشابه
Developmental Neurotoxicity: Some Old and New Issues
The developing central nervous system is often more vulnerable to injury than the adult one. Of the almost 200 chemicals known to be neurotoxic, many are developmental neurotoxicants. Exposure to these compounds in utero or during childhood can contribute to a variety of neurodevelopmental and neurological disorders. Two established developmental neurotoxicants, methylmercury and lead, and two ...
متن کاملA Retrospective Performance Assessment of the Developmental Neurotoxicity Study in Support of OECD Test Guideline 426
OBJECTIVE We conducted a review of the history and performance of developmental neurotoxicity (DNT) testing in support of the finalization and implementation of Organisation of Economic Co-operation and Development (OECD) DNT test guideline 426 (TG 426). INFORMATION SOURCES AND ANALYSIS In this review we summarize extensive scientific efforts that form the foundation for this testing paradigm...
متن کاملEvaluation of developmental neurotoxicity: some important issues focused on neurobehavioral development
Exposure of the developing organism to industrial chemicals and physical factors represents a serious risk factor for the development of neurobehavioral disorders, such as attention-deficit hyperactivity disorder, autism and mental retardation. Appropriate animal models are needed to test potentially harmful effects and mechanisms of developmental neurotoxicity of various chemical substances. H...
متن کاملManganese and Developmental Neurotoxicity.
Manganese (Mn) is an essential metal that plays a fundamental role for brain development and functioning. Environmental exposure to Mn may lead to accumulation in the basal ganglia and development of Parkinson-like disorders. The most recent research is focusing on early-life overexposure to Mn and the potential vulnerability of younger individuals to Mn toxicity also in regard to cognitive and...
متن کاملMethylmercury exposure and developmental neurotoxicity
We are concerned that certain aspects of the systematic review on methylmercury (MeHg) exposure from seafood consumption and the risk of developmental neurotoxicity published in the Bulletin of World Health Organization could be misinterpreted.1 Specifically, the review does not address the issue of whether naturally-occurring, background levels of prenatal exposure to MeHg from maternal fish c...
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ژورنال
عنوان ژورنال: Congenital Anomalies
سال: 2012
ISSN: 0914-3505
DOI: 10.1111/j.1741-4520.2012.00374.x